diff --git a/icu4c/source/CMakeLists.txt b/icu4c/source/CMakeLists.txt
new file mode 100644
index 00000000000..96c89a25454
--- /dev/null
+++ b/icu4c/source/CMakeLists.txt
@@ -0,0 +1,55 @@
+cmake_minimum_required(VERSION 3.16)
+
+project(icu4c)
+
+set(CMAKE_ARCHIVE_OUTPUT_DIRECTORY ${CMAKE_BINARY_DIR}/lib)
+set(CMAKE_LIBRARY_OUTPUT_DIRECTORY ${CMAKE_BINARY_DIR}/bin)
+set(CMAKE_RUNTIME_OUTPUT_DIRECTORY ${CMAKE_BINARY_DIR}/bin)
+
+add_library(icu_defaults INTERFACE)
+target_compile_definitions(icu_defaults INTERFACE U_ATTRIBUTE_DEPRECATED=)
+
+if(WIN32)
+    target_compile_definitions(icu_defaults INTERFACE
+        $<$<NOT:$<BOOL:${BUILD_SHARED_LIBS}>>:U_STATIC_IMPLEMENTATION>
+        WIN64
+        WIN32
+        WINVER=0x0601
+        _WIN32_WINNT=0x0601
+        _CRT_SECURE_NO_DEPRECATE
+        _MBCS
+        _HAS_EXCEPTIONS=0
+        $<$<CONFIG:Debug>:_DEBUG>)
+else()
+    target_compile_definitions(icu_defaults INTERFACE
+        _REENTRANT U_HAVE_ELF_H=1 U_HAVE_STRTOD_L=1 U_HAVE_XLOCALE_H=0)
+endif()
+
+if(MSVC)
+    target_compile_options(icu_defaults INTERFACE /utf-8)
+endif()
+
+add_library(icu_lib_defaults INTERFACE)
+target_link_libraries(icu_lib_defaults INTERFACE icu_defaults)
+
+if(WIN32)
+    target_compile_definitions(icu_lib_defaults INTERFACE _HAS_EXCEPTIONS=0)
+endif()
+
+macro(icu_add_sources target_name)
+    file(STRINGS sources.txt sources)
+    target_sources("${target_name}" PRIVATE "${sources}")
+endmacro()
+
+add_subdirectory(common)
+add_subdirectory(i18n)
+add_subdirectory(io)
+add_subdirectory(tools)
+add_subdirectory(stubdata)
+
+include(CTest)
+
+if(BUILD_TESTING)
+    add_test(NAME icuinfo COMMAND icuinfo WORKING_DIRECTORY ${CMAKE_RUNTIME_OUTPUT_DIRECTORY})
+    add_subdirectory(test)
+endif()
diff --git a/icu4c/source/common/CMakeLists.txt b/icu4c/source/common/CMakeLists.txt
new file mode 100644
index 00000000000..9c6be92f192
--- /dev/null
+++ b/icu4c/source/common/CMakeLists.txt
@@ -0,0 +1,9 @@
+add_library(icuuc)
+icu_add_sources(icuuc)
+target_link_libraries(icuuc PRIVATE icu_defaults icu_lib_defaults icudt)
+target_include_directories(icuuc PUBLIC ${CMAKE_CURRENT_SOURCE_DIR})
+target_compile_definitions(icuuc PRIVATE U_COMMON_IMPLEMENTATION)
+
+if(WIN32)
+    target_compile_definitions(icuuc PRIVATE $<$<CONFIG:Debug>:RBBI_DEBUG> U_PLATFORM_USES_ONLY_WIN32_API=1)
+endif()
diff --git a/icu4c/source/data/makedata.mak b/icu4c/source/data/makedata.mak
index 1fe8c88593c..45f593cdab7 100644
--- a/icu4c/source/data/makedata.mak
+++ b/icu4c/source/data/makedata.mak
@@ -284,7 +284,13 @@ ICU_DATA_BUILD_VERBOSE=
 # Three main targets: tools, core data, and test data.
 # Keep track of whether they are built via timestamp files.
 
-$(TOOLS_TS): "$(ICUTOOLS)\genrb\$(CFGTOOLS)\genrb.exe" "$(ICUTOOLS)\gencnval\$(CFGTOOLS)\gencnval.exe" "$(ICUTOOLS)\gencfu\$(CFGTOOLS)\gencfu.exe" "$(ICUTOOLS)\icupkg\$(CFGTOOLS)\icupkg.exe" "$(ICUTOOLS)\makeconv\$(CFGTOOLS)\makeconv.exe" "$(ICUPBIN)\pkgdata.exe"
+GENRB_DIR=$(ICUTOOLS)\genrb\$(CFGTOOLS)
+GENCNVAL_DIR=$(ICUTOOLS)\gencnval\$(CFGTOOLS)
+GENCFU_DIR=$(ICUTOOLS)\gencfu\$(CFGTOOLS)
+ICUPKG_DIR=$(ICUTOOLS)\icupkg\$(CFGTOOLS)
+MAKECONV_DIR=$(ICUTOOLS)\makeconv\$(CFGTOOLS)
+
+$(TOOLS_TS): "$(GENRB_DIR)\genrb.exe" "$(GENCNVAL_DIR)\gencnval.exe" "$(GENCFU_DIR)\gencfu.exe" "$(ICUPKG_DIR)\icupkg.exe" "$(MAKECONV_DIR)\makeconv.exe" "$(ICUPBIN)\pkgdata.exe"
 	@echo "timestamp" > $(TOOLS_TS)
 
 # On Unix, Python generates at configure time a list of Makefile rules.
diff --git a/icu4c/source/i18n/CMakeLists.txt b/icu4c/source/i18n/CMakeLists.txt
new file mode 100644
index 00000000000..7d1fe262f09
--- /dev/null
+++ b/icu4c/source/i18n/CMakeLists.txt
@@ -0,0 +1,5 @@
+add_library(icui18n)
+icu_add_sources(icui18n)
+target_link_libraries(icui18n PRIVATE icu_lib_defaults icuuc)
+target_compile_definitions(icui18n PRIVATE U_I18N_IMPLEMENTATION)
+target_include_directories(icui18n PUBLIC ${CMAKE_CURRENT_SOURCE_DIR})
diff --git a/icu4c/source/io/CMakeLists.txt b/icu4c/source/io/CMakeLists.txt
new file mode 100644
index 00000000000..48e5e455b30
--- /dev/null
+++ b/icu4c/source/io/CMakeLists.txt
@@ -0,0 +1,5 @@
+add_library(icuio)
+icu_add_sources(icuio)
+target_link_libraries(icuio PRIVATE icu_lib_defaults icuuc icui18n)
+target_compile_definitions(icuio PRIVATE U_IO_IMPLEMENTATION)
+target_include_directories(icuio PUBLIC ${CMAKE_CURRENT_SOURCE_DIR})
diff --git a/icu4c/source/stubdata/CMakeLists.txt b/icu4c/source/stubdata/CMakeLists.txt
new file mode 100644
index 00000000000..a994d412b08
--- /dev/null
+++ b/icu4c/source/stubdata/CMakeLists.txt
@@ -0,0 +1,10 @@
+add_library(icudt)
+icu_add_sources(icudt)
+target_link_libraries(icudt PRIVATE icu_lib_defaults icuuc)
+target_compile_definitions(icudt PRIVATE U_COMMON_IMPLEMENTATION)
+
+add_custom_command(
+  TARGET icudt POST_BUILD
+  COMMAND ${CMAKE_COMMAND} -E echo "File with stubdata build time, used as a dependency to trigger fresh data build, since stubdata dll will overwrite the real one." > "${CMAKE_CURRENT_LIST_DIR}/stubdatabuilt.txt"
+	WORKING_DIRECTORY ${icu4c_SOURCE_DIR}/extra/uconv
+	VERBATIM)
diff --git a/icu4c/source/test/CMakeLists.txt b/icu4c/source/test/CMakeLists.txt
new file mode 100644
index 00000000000..d27fe462aa2
--- /dev/null
+++ b/icu4c/source/test/CMakeLists.txt
@@ -0,0 +1,8 @@
+add_subdirectory(cintltst)
+add_subdirectory(compat)
+add_subdirectory(fuzzer)
+add_subdirectory(intltest)
+add_subdirectory(iotest)
+#add_subdirectory(letest)
+add_subdirectory(testmap)
+#add_subdirectory(thaitest)
\ No newline at end of file
diff --git a/icu4c/source/test/cintltst/CMakeLists.txt b/icu4c/source/test/cintltst/CMakeLists.txt
new file mode 100644
index 00000000000..359f3005a65
--- /dev/null
+++ b/icu4c/source/test/cintltst/CMakeLists.txt
@@ -0,0 +1,96 @@
+add_executable(cintltst)
+target_link_libraries(cintltst PRIVATE icu_defaults icuuc ctestfw icui18n toolutil)
+
+if(BUILD_TESTING)
+    add_test(NAME cintltst COMMAND cintltst WORKING_DIRECTORY ${CMAKE_RUNTIME_OUTPUT_DIRECTORY})
+endif()
+
+target_sources(cintltst PRIVATE
+    bocu1tst.c
+    callcoll.c
+    calltest.c
+    capitst.c
+    cbiapts.c
+    cbididat.c
+    cbiditransformtst.c
+    cbiditst.c
+    cbkittst.c
+    ccaltst.c
+    ccapitst.c
+    ccolltst.c
+    cconvtst.c
+    cctest.c
+    ccurrtst.c
+    cdateintervalformattest.c
+    cdattst.c
+    cdetst.c
+    cdtdptst.c
+    cdtrgtst.c
+    cestst.c
+    cfintst.c
+    cformtst.c
+    cfrtst.c
+    cg7coll.c
+    cgendtst.c
+    chashtst.c
+    cintltst.c
+    citertst.c
+    cjaptst.c
+    cldrtest.c
+    cloctst.c
+    cmsccoll.c
+    cmsgtst.c
+    cnmdptst.c
+    cnormtst.c
+    cnumtst.c
+    cpluralrulestest.c
+    cposxtst.c
+    crelativedateformattest.c
+    crestst.c
+    creststn.c
+    cstrcase.c
+    cstrtest.c
+    cturtst.c
+    cucdapi.c
+    cucdtst.c
+    currtest.c
+    custrtrn.c
+    custrtst.c
+    cutiltst.c
+    encoll.c
+    eurocreg.c
+    hpmufn.c
+    idnatest.c
+    nccbtst.c
+    ncnvfbts.c
+    ncnvtst.c
+    nfsprep.c
+    nucnvtst.c
+    putiltst.c
+    reapits.c
+    sorttest.c
+    spooftest.c
+    spreptst.c
+    sprpdata.c
+    stdnmtst.c
+    tracetst.c
+    trie2test.c
+    trietest.c
+    ucnvseltst.c
+    ucptrietest.c
+    ucsdetst.c
+    udatatst.c
+    udatpg_test.c
+    uenumtst.c
+    uformattedvaluetst.c
+    ulistfmttest.c
+    unumberformattertst.c
+    unumberrangeformattertst.c
+    uregiontest.c
+    usettest.c
+    usrchtst.c
+    utexttst.c
+    utf16tst.c
+    utf8tst.c
+    utmstest.c
+    utransts.c)
\ No newline at end of file
diff --git a/icu4c/source/test/compat/CMakeLists.txt b/icu4c/source/test/compat/CMakeLists.txt
new file mode 100644
index 00000000000..d07b0ab7aa3
--- /dev/null
+++ b/icu4c/source/test/compat/CMakeLists.txt
@@ -0,0 +1,2 @@
+add_executable(compat tzdate.c)
+target_link_libraries(compat PRIVATE icu_defaults icuuc icui18n)
\ No newline at end of file
diff --git a/icu4c/source/test/fuzzer/CMakeLists.txt b/icu4c/source/test/fuzzer/CMakeLists.txt
new file mode 100644
index 00000000000..fe42bc4f74f
--- /dev/null
+++ b/icu4c/source/test/fuzzer/CMakeLists.txt
@@ -0,0 +1,22 @@
+add_library(fuzzer fuzzer_driver.cpp locale_util.cpp)
+target_link_libraries(fuzzer PRIVATE icu_defaults icuuc)
+
+function(add_fuzzer fuzzer_name)
+    add_executable(${fuzzer_name} ${fuzzer_name}.cpp)
+    target_link_libraries(${fuzzer_name} PRIVATE icu_defaults icuuc icui18n fuzzer)
+endfunction()
+
+add_fuzzer(break_iterator_fuzzer)
+add_fuzzer(collator_compare_fuzzer)
+add_fuzzer(collator_rulebased_fuzzer)
+add_fuzzer(converter_fuzzer)
+add_fuzzer(locale_fuzzer)
+add_fuzzer(number_format_fuzzer)
+add_fuzzer(ucasemap_fuzzer)
+add_fuzzer(uloc_canonicalize_fuzzer)
+add_fuzzer(uloc_for_language_tag_fuzzer)
+add_fuzzer(uloc_get_name_fuzzer)
+add_fuzzer(uloc_is_right_to_left_fuzzer)
+add_fuzzer(uloc_open_keywords_fuzzer)
+add_fuzzer(unicode_string_codepage_create_fuzzer)
+add_fuzzer(uregex_open_fuzzer)
\ No newline at end of file
diff --git a/icu4c/source/test/intltest/CMakeLists.txt b/icu4c/source/test/intltest/CMakeLists.txt
new file mode 100644
index 00000000000..ee612f5ace9
--- /dev/null
+++ b/icu4c/source/test/intltest/CMakeLists.txt
@@ -0,0 +1,177 @@
+add_executable(intltest)
+target_link_libraries(intltest PRIVATE icu_defaults ctestfw icuuc icui18n toolutil)
+
+if(BUILD_TESTING)
+    add_test(NAME intltest COMMAND intltest WORKING_DIRECTORY ${CMAKE_RUNTIME_OUTPUT_DIRECTORY})
+endif()
+
+target_sources(intltest PRIVATE
+    aliastst.cpp
+    allcoll.cpp
+    alphaindextst.cpp
+    apicoll.cpp
+    astrotst.cpp
+    bidiconf.cpp
+    bytestrietest.cpp
+    calcasts.cpp
+    callimts.cpp
+    calregts.cpp
+    caltest.cpp
+    caltztst.cpp
+    canittst.cpp
+    citrtest.cpp
+    collationtest.cpp
+    colldata.cpp
+    compactdecimalformattest.cpp
+    convtest.cpp
+    cpdtrtst.cpp
+    csdetest.cpp
+    currcoll.cpp
+    dadrcal.cpp
+    dadrfmt.cpp
+    datadrivennumberformattestsuite.cpp
+    dcfmapts.cpp
+    dcfmtest.cpp
+    decoll.cpp
+    displayoptions_test.cpp
+    dtfmapts.cpp
+    dtfmrgts.cpp
+    dtfmtrtts.cpp
+    dtfmttst.cpp
+    dtifmtts.cpp
+    dtptngts.cpp
+    encoll.cpp
+    erarulestest.cpp
+    escoll.cpp
+    ficoll.cpp
+    fldset.cpp
+    formatted_string_builder_test.cpp
+    formattedvaluetest.cpp
+    frcoll.cpp
+    g7coll.cpp
+    genderinfotest.cpp
+    icusvtst.cpp
+    idnaconf.cpp
+    idnaref.cpp
+    incaltst.cpp
+    intltest.cpp
+    itercoll.cpp
+    itformat.cpp
+    itmajor.cpp
+    itrbbi.cpp
+    itrbnf.cpp
+    itrbnfp.cpp
+    itrbnfrt.cpp
+    itspoof.cpp
+    ittrans.cpp
+    itutil.cpp
+    jacoll.cpp
+    jamotest.cpp
+    lcukocol.cpp
+    listformattertest.cpp
+    localebuildertest.cpp
+    localematchertest.cpp
+    locnmtst.cpp
+    loctest.cpp
+    lstmbetst.cpp
+    measfmttest.cpp
+    miscdtfm.cpp
+    mnkytst.cpp
+    msfmrgts.cpp
+    nmfmapts.cpp
+    nmfmtrt.cpp
+    normconf.cpp
+    nptrans.cpp
+    numberformattesttuple.cpp
+    numbertest_affixutils.cpp
+    numbertest_api.cpp
+    numbertest_decimalquantity.cpp
+    numbertest_doubleconversion.cpp
+    numbertest_modifiers.cpp
+    numbertest_parse.cpp
+    numbertest_patternmodifier.cpp
+    numbertest_patternstring.cpp
+    numbertest_permutation.cpp
+    numbertest_range.cpp
+    numbertest_simple.cpp
+    numbertest_skeletons.cpp
+    numfmtdatadriventest.cpp
+    numfmtspectest.cpp
+    numfmtst.cpp
+    numrgts.cpp
+    pluralmaptest.cpp
+    plurfmts.cpp
+    plurults.cpp
+    pptest.cpp
+    punyref.cpp
+    quantityformattertest.cpp
+    rbbiapts.cpp
+    rbbimonkeytest.cpp
+    rbbitst.cpp
+    regcoll.cpp
+    regextst.cpp
+    regiontst.cpp
+    reldatefmttest.cpp
+    reptest.cpp
+    restest.cpp
+    restsnew.cpp
+    scientificnumberformattertest.cpp
+    sdtfmtts.cpp
+    selfmts.cpp
+    sfwdchit.cpp
+    simpleformattertest.cpp
+    simplethread.cpp
+    srchtest.cpp
+    ssearch.cpp
+    static_unisets_test.cpp
+    strcase.cpp
+    string_segment_test.cpp
+    strtest.cpp
+    svccoll.cpp
+    tchcfmt.cpp
+    testidn.cpp
+    testidna.cpp
+    testutil.cpp
+    textfile.cpp
+    tfsmalls.cpp
+    thcoll.cpp
+    tmsgfmt.cpp
+    tokiter.cpp
+    transapi.cpp
+    transrt.cpp
+    transtst.cpp
+    trcoll.cpp
+    trnserr.cpp
+    tscoll.cpp
+    tsdate.cpp
+    tsdcfmsy.cpp
+    tsdtfmsy.cpp
+    tsmthred.cpp
+    tsnmfmt.cpp
+    tsputil.cpp
+    tstnorm.cpp
+    tstnrapi.cpp
+    tufmtts.cpp
+    tzbdtest.cpp
+    tzfmttst.cpp
+    tzoffloc.cpp
+    tzregts.cpp
+    tzrulets.cpp
+    tztest.cpp
+    ucaconf.cpp
+    ucdtest.cpp
+    ucharstrietest.cpp
+    unifiedcachetest.cpp
+    units_data_test.cpp
+    units_router_test.cpp
+    units_test.cpp
+    uobjtest.cpp
+    usettest.cpp
+    ustrtest.cpp
+    uts46test.cpp
+    utxttest.cpp
+    uvectest.cpp
+    v32test.cpp
+    windttst.cpp
+    winnmtst.cpp
+    winutil.cpp)
\ No newline at end of file
diff --git a/icu4c/source/test/iotest/CMakeLists.txt b/icu4c/source/test/iotest/CMakeLists.txt
new file mode 100644
index 00000000000..8ac69728b88
--- /dev/null
+++ b/icu4c/source/test/iotest/CMakeLists.txt
@@ -0,0 +1,6 @@
+add_executable(iotest filetst.c iotest.cpp stream.cpp strtst.c trnstst.c)
+target_link_libraries(iotest icu_defaults icuuc ctestfw icuio icui18n)
+
+if(BUILD_TESTING)
+    add_test(NAME iotest COMMAND iotest WORKING_DIRECTORY ${CMAKE_RUNTIME_OUTPUT_DIRECTORY})
+endif()
diff --git a/icu4c/source/test/letest/CMakeLists.txt b/icu4c/source/test/letest/CMakeLists.txt
new file mode 100644
index 00000000000..15e60f9ea4b
--- /dev/null
+++ b/icu4c/source/test/letest/CMakeLists.txt
@@ -0,0 +1,15 @@
+add_executable(letest)
+target_link_libraries(letest icu_defaults)
+target_sources(letest PRIVATE
+    FontObject.cpp
+    FontTableCache.cpp
+    PortableFontInstance.cpp
+    SimpleFontInstance.cpp
+    cfonts.cpp
+    cletest.c
+    cmaps.cpp
+    gendata.cpp
+    letest.cpp
+    letsutil.cpp
+    testdata.cpp
+    xmlreader.cpp)
\ No newline at end of file
diff --git a/icu4c/source/test/testmap/CMakeLists.txt b/icu4c/source/test/testmap/CMakeLists.txt
new file mode 100644
index 00000000000..0e6b030a5b5
--- /dev/null
+++ b/icu4c/source/test/testmap/CMakeLists.txt
@@ -0,0 +1,2 @@
+add_executable(testmap testmap.c)
+target_link_libraries(testmap icu_defaults icuuc)
\ No newline at end of file
diff --git a/icu4c/source/test/thaitest/CMakeLists.txt b/icu4c/source/test/thaitest/CMakeLists.txt
new file mode 100644
index 00000000000..1b1d410b4cf
--- /dev/null
+++ b/icu4c/source/test/thaitest/CMakeLists.txt
@@ -0,0 +1,2 @@
+add_executable(thaitest thaitest.cpp)
+target_link_libraries(thaitest icu_defaults)
\ No newline at end of file
diff --git a/icu4c/source/tools/CMakeLists.txt b/icu4c/source/tools/CMakeLists.txt
new file mode 100644
index 00000000000..97d2339448e
--- /dev/null
+++ b/icu4c/source/tools/CMakeLists.txt
@@ -0,0 +1,19 @@
+add_subdirectory(ctestfw)
+add_subdirectory(genbrk)
+add_subdirectory(genccode)
+add_subdirectory(gencfu)
+add_subdirectory(gencmn)
+add_subdirectory(gencnval)
+add_subdirectory(gendict)
+add_subdirectory(gennorm2)
+add_subdirectory(genrb)
+add_subdirectory(gensprep)
+add_subdirectory(gentest)
+add_subdirectory(icuexportdata)
+add_subdirectory(icuinfo)
+add_subdirectory(icupkg)
+add_subdirectory(icuswap)
+add_subdirectory(makeconv)
+add_subdirectory(pkgdata)
+add_subdirectory(toolutil)
+add_subdirectory(tzcode)
\ No newline at end of file
diff --git a/icu4c/source/tools/ctestfw/CMakeLists.txt b/icu4c/source/tools/ctestfw/CMakeLists.txt
new file mode 100644
index 00000000000..49a7247483b
--- /dev/null
+++ b/icu4c/source/tools/ctestfw/CMakeLists.txt
@@ -0,0 +1,5 @@
+add_library(ctestfw)
+icu_add_sources(ctestfw)
+target_link_libraries(ctestfw PRIVATE icu_defaults icuuc toolutil)
+target_include_directories(ctestfw PUBLIC ${CMAKE_CURRENT_SOURCE_DIR})
+target_compile_definitions(ctestfw PRIVATE T_CTEST_IMPLEMENTATION)
\ No newline at end of file
diff --git a/icu4c/source/tools/genbrk/CMakeLists.txt b/icu4c/source/tools/genbrk/CMakeLists.txt
new file mode 100644
index 00000000000..34063851e66
--- /dev/null
+++ b/icu4c/source/tools/genbrk/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(genbrk)
+icu_add_sources(genbrk)
+target_link_libraries(genbrk PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/genccode/CMakeLists.txt b/icu4c/source/tools/genccode/CMakeLists.txt
new file mode 100644
index 00000000000..abbfff9a33c
--- /dev/null
+++ b/icu4c/source/tools/genccode/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(genccode)
+icu_add_sources(genccode)
+target_link_libraries(genccode PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/gencfu/CMakeLists.txt b/icu4c/source/tools/gencfu/CMakeLists.txt
new file mode 100644
index 00000000000..0fee54b37a1
--- /dev/null
+++ b/icu4c/source/tools/gencfu/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(gencfu)
+icu_add_sources(gencfu)
+target_link_libraries(gencfu PRIVATE icu_defaults icuuc toolutil icui18n)
\ No newline at end of file
diff --git a/icu4c/source/tools/gencmn/CMakeLists.txt b/icu4c/source/tools/gencmn/CMakeLists.txt
new file mode 100644
index 00000000000..2d942b21748
--- /dev/null
+++ b/icu4c/source/tools/gencmn/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(gencmn)
+icu_add_sources(gencmn)
+target_link_libraries(gencmn PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/gencnval/CMakeLists.txt b/icu4c/source/tools/gencnval/CMakeLists.txt
new file mode 100644
index 00000000000..4067609abf9
--- /dev/null
+++ b/icu4c/source/tools/gencnval/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(gencnval)
+icu_add_sources(gencnval)
+target_link_libraries(gencnval PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/gendict/CMakeLists.txt b/icu4c/source/tools/gendict/CMakeLists.txt
new file mode 100644
index 00000000000..05b67fa4c75
--- /dev/null
+++ b/icu4c/source/tools/gendict/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(gendict)
+icu_add_sources(gendict)
+target_link_libraries(gendict PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/gennorm2/CMakeLists.txt b/icu4c/source/tools/gennorm2/CMakeLists.txt
new file mode 100644
index 00000000000..f832a10074e
--- /dev/null
+++ b/icu4c/source/tools/gennorm2/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(gennorm2)
+icu_add_sources(gennorm2)
+target_link_libraries(gennorm2 PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/genrb/CMakeLists.txt b/icu4c/source/tools/genrb/CMakeLists.txt
new file mode 100644
index 00000000000..09f1387a303
--- /dev/null
+++ b/icu4c/source/tools/genrb/CMakeLists.txt
@@ -0,0 +1,6 @@
+add_executable(genrb)
+icu_add_sources(genrb)
+target_link_libraries(genrb PRIVATE icu_defaults icuuc toolutil icui18n)
+
+add_executable(derb derb.cpp)
+target_link_libraries(derb PRIVATE icu_defaults icuuc toolutil icuio icui18n)
\ No newline at end of file
diff --git a/icu4c/source/tools/gensprep/CMakeLists.txt b/icu4c/source/tools/gensprep/CMakeLists.txt
new file mode 100644
index 00000000000..d3fb80e10e7
--- /dev/null
+++ b/icu4c/source/tools/gensprep/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(gensprep)
+icu_add_sources(gensprep)
+target_link_libraries(gensprep PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/gentest/CMakeLists.txt b/icu4c/source/tools/gentest/CMakeLists.txt
new file mode 100644
index 00000000000..fbe83b5d96e
--- /dev/null
+++ b/icu4c/source/tools/gentest/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(gentest)
+icu_add_sources(gentest)
+target_link_libraries(gentest PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/icuexportdata/CMakeLists.txt b/icu4c/source/tools/icuexportdata/CMakeLists.txt
new file mode 100644
index 00000000000..640f5325227
--- /dev/null
+++ b/icu4c/source/tools/icuexportdata/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(icuexportdata)
+icu_add_sources(icuexportdata)
+target_link_libraries(icuexportdata PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/icuinfo/CMakeLists.txt b/icu4c/source/tools/icuinfo/CMakeLists.txt
new file mode 100644
index 00000000000..852e8bc5259
--- /dev/null
+++ b/icu4c/source/tools/icuinfo/CMakeLists.txt
@@ -0,0 +1,6 @@
+add_executable(icuinfo)
+icu_add_sources(icuinfo)
+target_link_libraries(icuinfo PRIVATE icu_defaults icuuc toolutil icui18n)
+
+add_library(testplug testplug.c)
+target_link_libraries(testplug PRIVATE icu_lib_defaults icuuc)
diff --git a/icu4c/source/tools/icupkg/CMakeLists.txt b/icu4c/source/tools/icupkg/CMakeLists.txt
new file mode 100644
index 00000000000..ee15c1ffad8
--- /dev/null
+++ b/icu4c/source/tools/icupkg/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(icupkg)
+icu_add_sources(icupkg)
+target_link_libraries(icupkg PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/icuswap/CMakeLists.txt b/icu4c/source/tools/icuswap/CMakeLists.txt
new file mode 100644
index 00000000000..8863a7768c7
--- /dev/null
+++ b/icu4c/source/tools/icuswap/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(icuswap)
+icu_add_sources(icuswap)
+target_link_libraries(icuswap PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/makeconv/CMakeLists.txt b/icu4c/source/tools/makeconv/CMakeLists.txt
new file mode 100644
index 00000000000..7020da75bc7
--- /dev/null
+++ b/icu4c/source/tools/makeconv/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(makeconv)
+icu_add_sources(makeconv)
+target_link_libraries(makeconv PRIVATE icu_defaults icuuc toolutil)
\ No newline at end of file
diff --git a/icu4c/source/tools/pkgdata/CMakeLists.txt b/icu4c/source/tools/pkgdata/CMakeLists.txt
new file mode 100644
index 00000000000..4e06c361360
--- /dev/null
+++ b/icu4c/source/tools/pkgdata/CMakeLists.txt
@@ -0,0 +1,20 @@
+add_executable(pkgdata)
+icu_add_sources(pkgdata)
+target_link_libraries(pkgdata PRIVATE icu_defaults icuuc toolutil)
+
+add_dependencies(pkgdata gencnval)
+
+add_custom_command(
+  TARGET pkgdata POST_BUILD
+  COMMAND nmake /nologo /f ${icu4c_SOURCE_DIR}/data/makedata.mak
+	ICUMAKE=${icu4c_SOURCE_DIR}/data
+	DLL_OUTPUT=${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
+	ICUPBIN=${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
+	GENRB_DIR=${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
+	GENCNVAL_DIR=${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
+	GENCFU_DIR=${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
+	ICUPKG_DIR=${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
+	MAKECONV_DIR=${CMAKE_RUNTIME_OUTPUT_DIRECTORY}
+	CFG=${CMAKE_CXX_COMPILER_ARCHITECTURE_ID}\\$<CONFIG>
+	$<$<CONFIG:Debug>:DEBUG=true>
+  VERBATIM)
\ No newline at end of file
diff --git a/icu4c/source/tools/toolutil/CMakeLists.txt b/icu4c/source/tools/toolutil/CMakeLists.txt
new file mode 100644
index 00000000000..ff3f0df75ec
--- /dev/null
+++ b/icu4c/source/tools/toolutil/CMakeLists.txt
@@ -0,0 +1,5 @@
+add_library(toolutil)
+icu_add_sources(toolutil)
+target_link_libraries(toolutil PRIVATE icu_lib_defaults icuuc icui18n)
+target_include_directories(toolutil PUBLIC ${CMAKE_CURRENT_SOURCE_DIR})
+target_compile_definitions(toolutil PRIVATE U_TOOLUTIL_IMPLEMENTATION)
\ No newline at end of file
diff --git a/icu4c/source/tools/tzcode/CMakeLists.txt b/icu4c/source/tools/tzcode/CMakeLists.txt
new file mode 100644
index 00000000000..95e35a32010
--- /dev/null
+++ b/icu4c/source/tools/tzcode/CMakeLists.txt
@@ -0,0 +1,3 @@
+add_executable(icuzdump icuzdump.cpp)
+target_link_libraries(icuzdump PRIVATE
+    icu_defaults icuuc toolutil icui18n icuio)
\ No newline at end of file