diff --git a/icu4c/source/layout/LETypes.h b/icu4c/source/layout/LETypes.h
index 3cd779ce484..d4a103b0fd8 100644
--- a/icu4c/source/layout/LETypes.h
+++ b/icu4c/source/layout/LETypes.h
@@ -9,7 +9,7 @@
 #ifndef __LETYPES_H
 #define __LETYPES_H
 
-#if !defined(LE_USE_CMEMORY) && (defined(U_LAYOUT_IMPLEMENTATION) || defined(U_LAYOUTEX_IMPLEMENTATION))
+#if !defined(LE_USE_CMEMORY) && (defined(U_LAYOUT_IMPLEMENTATION) || defined(U_LAYOUTEX_IMPLEMENTATION) || defined(U_STATIC_IMPLEMENTATION) || defined(U_COMBINED_IMPLEMENTATION))
 #define LE_USE_CMEMORY
 #endif