diff --git a/icu4j/main/tests/core/src/com/ibm/icu/dev/test/calendar/CalendarRegressionTest.java b/icu4j/main/tests/core/src/com/ibm/icu/dev/test/calendar/CalendarRegressionTest.java
index 1d21f063305..936ebe4a621 100644
--- a/icu4j/main/tests/core/src/com/ibm/icu/dev/test/calendar/CalendarRegressionTest.java
+++ b/icu4j/main/tests/core/src/com/ibm/icu/dev/test/calendar/CalendarRegressionTest.java
@@ -2619,5 +2619,26 @@ public class CalendarRegressionTest extends com.ibm.icu.dev.test.TestFmwk {
                          TESTS[i][2], cal.getType());
         }
     }
+
+    void VerifyNoAssertWithSetGregorianChange(String timezone) {
+        TimeZone zone = TimeZone.getTimeZone(timezone);
+        GregorianCalendar cal = new GregorianCalendar(zone, Locale.ENGLISH);
+        cal.setTime(new Date());
+        // The beginning of ECMAScript time, namely -(2**53)
+        long startOfTime = -9007199254740992L;
+
+        cal.setGregorianChange(new Date(startOfTime));
+        cal.get(Calendar.ZONE_OFFSET);
+        cal.get(Calendar.DST_OFFSET);
+    }
+
+    @Test
+    public void TestAsiaManilaAfterSetGregorianChange22043() {
+        VerifyNoAssertWithSetGregorianChange("Asia/Manila");
+        for (String id : TimeZone.getAvailableIDs()) {
+            VerifyNoAssertWithSetGregorianChange(id);
+        }
+    }
+
 }
 //eof