diff --git a/tools/cldr/cldr-to-icu/src/main/java/org/unicode/icu/tool/cldrtoicu/IcuTextWriter.java b/tools/cldr/cldr-to-icu/src/main/java/org/unicode/icu/tool/cldrtoicu/IcuTextWriter.java
index 93f23524c90..c302f74798f 100644
--- a/tools/cldr/cldr-to-icu/src/main/java/org/unicode/icu/tool/cldrtoicu/IcuTextWriter.java
+++ b/tools/cldr/cldr-to-icu/src/main/java/org/unicode/icu/tool/cldrtoicu/IcuTextWriter.java
@@ -68,6 +68,13 @@ final class IcuTextWriter {
         this.icuData = checkNotNull(icuData);
     }
 
+    // ICU-22781: start section
+    // TODO: remove once ICU-22781 is resolved
+    private final static RbPath LOCALE_PER_BILLION = RbPath.of("concentr", "portion-per-1e9");
+    private final static RbPath SUPLEMENTAL_UNITS = RbPath.of("idValidity", "unit", "regular");
+    private final static RbValue SUPLEMENTAL_PER_BILLION = RbValue.of("concentr-portion-per-1e9");
+    // ICU-22781: end section
+
     // TODO: Write a UTF-8 header (see https://unicode-org.atlassian.net/browse/ICU-10197).
     private void writeTo(PrintWriter out, List<String> header) {
         out.write('\uFEFF');
@@ -93,6 +100,17 @@ final class IcuTextWriter {
 
         RbPath lastPath = RbPath.of();
         for (RbPath path : icuData.getPaths()) {
+            // ICU-22781: start section
+            boolean mightBeSupplemental = false;
+            if (path.contains(LOCALE_PER_BILLION)) {
+                // I tried logging here, but it is too noisy.
+                // About 20 entries (and logging 20 lines) per locale.
+                continue;
+            }
+            if (path.contains(SUPLEMENTAL_UNITS)) {
+                mightBeSupplemental = true;
+            }
+            // ICU-22781: end section
             // Close any blocks up to the common path length. Since paths are all distinct, the
             // common length should always be shorter than either path. We add 1 since we must also
             // account for the implicit root segment.
@@ -101,7 +119,14 @@ final class IcuTextWriter {
             closeLastPath(commonDepth, out);
             // After opening the value will be ready for the next value to be written.
             openNextPath(path, out);
-            valueWasInline = appendValues(icuData.getName(), path, icuData.get(path), out);
+            List<RbValue> values = icuData.get(path);
+            // ICU-22781: start section
+            if (mightBeSupplemental) {
+                System.out.println("(skipping " + SUPLEMENTAL_PER_BILLION + " until ICU-22781 is fixed)");
+                values.remove(SUPLEMENTAL_PER_BILLION);
+            }
+            // ICU-22781: end section
+            valueWasInline = appendValues(icuData.getName(), path, values, out);
             lastPath = path;
         }
         closeLastPath(0, out);