diff --git a/icu4c/source/common/ucurr.cpp b/icu4c/source/common/ucurr.cpp
index f478d8094ff..309b86e0ae4 100644
--- a/icu4c/source/common/ucurr.cpp
+++ b/icu4c/source/common/ucurr.cpp
@@ -1963,6 +1963,7 @@ static const struct CurrencyList {
     {"UYI", UCURR_UNCOMMON|UCURR_NON_DEPRECATED},
     {"UYP", UCURR_COMMON|UCURR_DEPRECATED},
     {"UYU", UCURR_COMMON|UCURR_NON_DEPRECATED},
+    {"UYW", UCURR_UNCOMMON|UCURR_NON_DEPRECATED},
     {"UZS", UCURR_COMMON|UCURR_NON_DEPRECATED},
     {"VEB", UCURR_COMMON|UCURR_DEPRECATED},
     {"VEF", UCURR_COMMON|UCURR_NON_DEPRECATED},
diff --git a/icu4c/source/test/cintltst/currtest.c b/icu4c/source/test/cintltst/currtest.c
index 514278ad588..e35333d320c 100644
--- a/icu4c/source/test/cintltst/currtest.c
+++ b/icu4c/source/test/cintltst/currtest.c
@@ -83,6 +83,12 @@ static void TestEnumList(void) {
     expectInList("XEU", UCURR_UNCOMMON|UCURR_DEPRECATED, TRUE);
     expectInList("XEU", UCURR_UNCOMMON|UCURR_NON_DEPRECATED, FALSE);
 
+    // ICU-21622
+    expectInList("UYW", UCURR_ALL, TRUE);
+    expectInList("UYW", UCURR_COMMON, FALSE);
+    expectInList("UYW", UCURR_UNCOMMON, TRUE);
+    expectInList("UYW", UCURR_DEPRECATED, FALSE);
+    expectInList("UYW", UCURR_NON_DEPRECATED, TRUE);
 }
 
 static void TestEnumListReset(void) {
diff --git a/icu4c/source/test/testdata/structLocale.txt b/icu4c/source/test/testdata/structLocale.txt
index 5c81e17ec3b..2cbd39998f7 100644
--- a/icu4c/source/test/testdata/structLocale.txt
+++ b/icu4c/source/test/testdata/structLocale.txt
@@ -1363,6 +1363,10 @@ structLocale:table(nofallback){
             "",
             "",
         }
+        UYW{
+            "",
+            "",
+        }
         UZS{
             "",
             "",
@@ -1630,6 +1634,7 @@ structLocale:table(nofallback){
         UAH{""}
         USD{""}
         UYU{""}
+        UYW{""}
         VEF{""}
         VND{""}
         XCD{""}
@@ -3683,6 +3688,14 @@ structLocale:table(nofallback){
             many{""}
             other{""}
         }
+        UYW{
+            zero{""}
+            one{""}
+            two{""}
+            few{""}
+            many{""}
+            other{""}
+        }
         UZS{
             zero{""}
             one{""}
diff --git a/icu4j/main/tests/core/src/com/ibm/icu/dev/test/util/CurrencyTest.java b/icu4j/main/tests/core/src/com/ibm/icu/dev/test/util/CurrencyTest.java
index 103b006bbf1..c8bc708565a 100644
--- a/icu4j/main/tests/core/src/com/ibm/icu/dev/test/util/CurrencyTest.java
+++ b/icu4j/main/tests/core/src/com/ibm/icu/dev/test/util/CurrencyTest.java
@@ -570,6 +570,17 @@ public class CurrencyTest extends TestFmwk {
                 metainfo.currencies(filter.withTender()));
     }
 
+    @Test
+    public void TestFullCurrencyList() {
+        CurrencyMetaInfo metainfo = CurrencyMetaInfo.getInstance();
+        if (metainfo == null) {
+            errln("Unable to get CurrencyMetaInfo instance.");
+            return;
+        }
+        List<String> currencies = metainfo.currencies(null);
+        assertTrue("Full currencies list should include UYW", currencies.contains("UYW")); // ICU-21622
+    }
+
     // Coverage-only test of the CurrencyMetaInfo class
     @Test
     public void TestCurrencyMetaInfo() {